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May 8, 20241 min read

How does collagen production decline with age?

Short answer: Collagen production declines with age due to a combination of intrinsic and extrinsic factors.

Detailed answer

Collagen is a protein that provides structural support and elasticity to the skin. As we age, our bodies naturally produce less collagen. This is primarily due to a decrease in the activity of fibroblasts, the cells responsible for collagen synthesis. Additionally, the cross-linking of collagen fibers increases, leading to a less flexible and more brittle collagen structure. Extrinsic factors such as sun exposure, smoking, and pollution can further accelerate the decline of collagen production. UV radiation, in particular, damages collagen fibers and inhibits collagen synthesis by triggering the production of enzymes that break down collagen. This process, coupled with the natural decrease in collagen production, contributes to the visible signs of aging, including wrinkles, sagging skin, and loss of firmness.

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