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Psoriasis is a chronic autoimmune skin condition characterized by patches of red, itchy, and scaly skin. While the exact cause of psoriasis is not known, it is believed to be a combination of genetic and environmental factors. Hormonal changes can potentially trigger or exacerbate psoriasis in individuals with Turner syndrome. Turner syndrome is a genetic disorder that affects females, resulting in the absence of part or all of one X chromosome. This can lead to hormonal imbalances, including decreased levels of estrogen. Estrogen plays a role in regulating the immune system and maintaining a healthy skin barrier. The decrease in estrogen levels during Turner syndrome can disrupt the immune system's balance and compromise the skin's ability to function properly, potentially triggering psoriasis or worsening existing psoriasis. It is important for individuals with Turner syndrome to work closely with their healthcare provider to manage hormone levels and address any skin concerns.